Pharmacodynamic indices for rifampicin, clarithromycin, amikacin, and moxifloxacin are seldom met. C max/MIC or AUC/MIC ratios associated with bactericidal activity were seldom met 57% of patients achieved target ratios for ethambutol, versus 42% for clarithromycin, 19% for amikacin, 18% for rifampicin, and 11% for moxifloxacin.Ĭonclusions: Currently recommended regimens for MAC lung disease yield important pharmacologic interactions and low concentrations of key drugs including macrolides. Concurrent administration of rifampicin led to 68%, 23%, and 10% decreases in C max of clarithromycin, azithromycin, and moxifloxacin. Peak serum concentrations (C max) below target range were frequent for ethambutol (48% of patients) clarithromycin (56%) and azithromycin (35%). Measurements and Main Results: We included 531 pharmacokinetic analyses, performed for 481 patients (84% females mean age, 63 yr mean body mass index, 21.6). Minimum inhibitory concentrations (MIC) of their MAC isolates were retrieved for pharmacodynamic calculations. Methods: We retrospectively collected pharmacokinetic data of all patients treated for MAC lung disease in the Adult Care Unit at National Jewish Health, Denver, Colorado, in the January 2006 to January 2010 period we retrospectively calculated areas under the time-concentration curve (AUC). Objectives: To study pharmacokinetics, pharmacodynamics, and drug interactions of multidrug treatment regimens in a large cohort of patients with MAC lung disease. This results, in part, from incomplete understanding of the pharmacokinetics and pharmacodynamics of the drugs. Rationale: Currently recommended multidrug treatment regimens for Mycobacterium avium complex (MAC) lung disease yield limited cure rates.
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Postico has a powerful graphical structure editor for creating and altering tables.Īdd a column, edit data types, set a default value.Ĭolumns, indexes and constraints are unified in a single editor, so you see everything at once.Īnd the more technically inclined can view the structure as raw SQL (DDL view). Powerful features like the foreign key picker or the row detail sidebar make editing all kinds of tables a breeze. Auto-format SQL queries with Ctrl-F: pgFormatter is now built in!Ĭlick a table in the sidebar, and see the data instantly.Edit SQL files with other text editors like VS Code, Atom, Sublime, Textmate, ….Drag any SQL file into the sidebar to add it to Postico.Postico autosaves changes so you never lose your work.Open the same file in multiple tabs or windows.Create multiple SQL files and organize them into folders.The new SQL query editor makes working with a lot of queries easier than ever: If you'd like to know more about Postico 1.5, click here. Postico 2 is the next major version coming after Postico 1.5. Whether you want to enter data, search data, or perform SQL queries, Postico has you covered. Our customers range from researchers and analysts to app developers and students. Postico 2 is a database app with a very strong focus on its core audience: people who use databases. While Postico 2 is our latest and greatest version of Postico (see whats new in the changelog), we continue to support Postico 1.5. If you have an older Mac, we also have old versions of Postico available. Schroer Temples of Song in Silius Italicus Alison Keith Romuleos superabit voce nepotes: Remembering Romulus in Silius Italicus Claire Stocks Hannibal Redivivus: Fear and Haunting Memory in Silius Italicus Angeliki N.Postico 2 is compatible with PostgreSQL 8.0 or later, Amazon Redshift, CockroachDB, Greenplum, and others. Bernstein Part 3 Historical Challenges to ‘National’ Epic Silius Italicus as an Interpreter of Virgil: Dido and Anna Sergio Casali Pompey and Aemilius Paulus, or the Epic Genre between Lucan and Silius Italicus Nicola Lanzarone From the Rubicon to the Alps: Re-reading Eumolpus’ Caesar in Light of Silius Italicus’ Hannibal Stefano Poletti Part 4 Viewing Roman History (and Literature) from the Inside Scaevola’s aristeia: A Complementary Reworking of a Historical Source and the Epic Tradition Filippo Fabbri Exul in orbe toto, or, How to Map Future Power in Silius Italicus Clayton A. Roumpou, Clayton Schroer, Claire Stocks.Ībbreviations Notes on Contributors Introduction: Silius Italicus and the Tradition of the Roman Historical Epos Antony Augoustakis and Marco Fucecchi Part 1 The Historical Epic Tradition Silius Italicus and the Conventions of Historical Epic at Rome Gesine Manuwald Silius Italicus between Epos and Historiography Paolo Esposito Part 2 Rethinking Roman ‘Mythical History’ Silius Ciceronianus: Regulus as a Reflection of Cicero in Punica 6 Thomas Baier Silius Italicus and Ovid’s Roman History Raymond Marks Claudian’s Silius Neil W. Bernstein, Sergio Casali, Paolo Esposito, Filippo Fabbri, Alison Keith, Nicola Lanzarone, Gesine Manuwald, Raymond Marks, Stefano Poletti, Angeliki N. He is the author of some monographs on Flavian epic poems (Valerius Flaccus’ Argonautica and Silius’ Punica) as well as many articles on various topics in Latin literature.Ĭontributors are Thomas Baier, Neil W. His research interests include Latin literature from the Augustan age to the Ist century CE, with particular regard to epic poetry. Marco Fucecchi is Associate professor of Latin language and literature at the University of Udine (Italy). He is the author of many monographs and edited volumes on various topics in classical literature. His research interests include Latin imperial epic, Roman comedy and historiography, women in antiquity, classical reception, and gender theory. Antony Augoustakis is Professor of Classics at the University of Illinois at Urbana-Champaign in Urbana, Illinois, US. Slight imperfections are typical with this kind of product and, in fact, often enhance the value. Most figures we sell are collectible, made in limited runs, and are often hand-painted or hand-assembled. Please note that by purchasing goods from, you have agreed to the following terms.Īll sales are final at. We have developed what we believe is a fair return policy, as stated below. Many of our products are collectible and have certain conditions under which they must be returned in order to keep their value. Thank you for shopping with ! We hope that you enjoy your new purchase, and we are grateful for your business. does not guarantee product box/packaging. may cancel/refund orders at any time due to stock limitations, quality problems, inaccurate information from customers, fraud risk analysis, or any other reason. will not modify, reroute or cancel an order once placed. To see the most up-to-date estimate on a product’s arrival please visit the product page. Pre-orders are for items that are in development and are subject to shifting in-stock dates. All pre-order sales are final, with no refunds. Try your shoes on indoors in a carpeted area to avoid making them ineligible for a return.Īll Kidrobot & NECA sales are final at.
Copy editor or manuscript editor, who prepares the copy for conversion into printed form.Project editor or production editor, who sees the copy through its stages from manuscript to bound book and usually assumes most of the budget and schedule responsibilities.Acquisitions editor (or commissioning editor in Britain), who contracts with the author to produce the copy.Within the publishing environment, editors of scholarly books are of three main types, each with particular responsibilities: Editor Jack Breibart in the San Francisco Chronicle newsroom, 1994. These editors may have the title of layout or design editor or (more so in the past) makeup editor. They may choose the layout of the publication and communicate with the printer. and Australian newspapers, the term is sub-editor. In some positions, they design pages and select news stories for inclusion. Īt newspapers and wire services, press or copy editors write headlines and work on more substantive issues, such as ensuring accuracy, fairness, and taste. Changes to the publishing industry since the 1980s have resulted in nearly all copy editing of book manuscripts being outsourced to freelance copy editors. Finding marketable ideas and presenting them to appropriate authors are the responsibilities of a sponsoring editor.Ĭopy editors correct spelling, grammar and align writings to house style. Obtaining manuscripts or recruiting authors is the role of an acquisitions editor or a commissioning editor in a publishing house. In the book publishing industry, editors may organize anthologies and other compilations, produce definitive editions of a classic author's works (scholarly editor), and organize and manage contributions to a multi-author book (symposium editor or volume editor). newspapers, the level below the top editor is usually the managing editor. Mid-level newspaper editors often manage or help to manage sections, such as business, sports and features. A frequent and highly regarded contributor to a magazine may acquire the title of editor-at-large or contributing editor. The top editor at many publications may be known as the chief editor, executive editor, or simply the editor. The smaller the publication, the more these roles overlap. Senior executive editors are responsible for developing a product for its final release. Typically, one finds editorial assistants reporting to the senior-level editorial staff and directors who report to senior executive editors. There are various editorial positions in publishing. Previous front pages are affixed to the wall behind them. Editors work on producing an issue of Bild, West Berlin, 1977. Nevertheless, performing DoEs with a large number of factors may be challenging, time-consuming, and expensive. Several scientific publications have proven the successful application of design-of-experiment (DoE) in chromatography method development. CEX separations are complex and governed by multiple factors. However, the development of CEX methods in a time and resource-efficient manner constitutes a bottleneck in product characterization. In this presentation, we demonstrate how to use JMP Pro 16 Profiler Simulation feature with Graph Builder to achieve an extensive and insightful exploration of the formulation space applicable to diverse fields.Ĭation-exchange chromatography (CEX) is the industry gold standard for the analysis of biopharmaceutical charge variants. Indeed, under certain assumptions, this coding strategy enables one to interpolate and consider missing compositions not present in the original DOE. So, we recoded those two factors as continuous and mixture variables, derived the equivalent regression model, and reran the simulations. At that point, to be able to identify promising subregions, we needed to overcome the discreteness of the space. However, at the data analysis stage, even after considering thousands of simulated hypothetical formulations, none of them was predicted to meet the desired properties. We created the DOE treating them as categorical due to the experimental constraints. The first three variables represent different compositions for making Chemical A, B and C, respectively, and as such, can be coded both as categorical factors, as well as continuous mixture variables. The formulation space consists of four input variables: Chemical A Type, Chemical B Type, Chemical C Type, and Chemical D Content. This case study investigates chemical mixtures to achieve optimal properties using design of experiment (DOE) data. Whether your work can be planned or is a wild path of exploration and serendipity, JMP has the modes to make your work speedy, efficient and productive, while keeping you in an environment of discovery. But there can be “easy buttons” along the way, and you can create your own “easy buttons” for the steps that you plan to take again. The analytic process is fundamentally interactive, and JMP supports interactivity. You must be able to pursue clues, identify things, drill down to details, and adapt to new conditions. The problem is that the steps are not always the same in each situation or in each set of data – the analysis has to be interactive. JMP is built for discovery, but discovery is not just happening to see something in a graph it usually involves a lot of work and many process steps. JMP Presenters: John Sall, Julian Parris, Mandy Chambers, Ryan Lekivetz, Rebecca Lyzinski and Aurora Tiffany-Davis The Flow of Discovery: Automating the standard paths and enabling the non-standard paths. These brief streaks of light (often called “shooting stars”) are meteors. When meteoroids enter Earth’s atmosphere, they produce brilliant streaks of light that can be seen in our sky. Meteoroids are small particles - often no bigger than a grain of sand - that orbit our Sun. As comets move close to the Sun, they develop tails of dust and ionized gas millions of kilometers long.Īdditional information about comets is available at Ice in the Solar System Meteors, Meteoroids, and Meteorites As the frozen gases sublimate, they form a thin atmosphere around the nucleus (the coma) that can make the comet appear as a large glowing cloud as big as a planet. The center (nucleus) of a comet ranges from 0.1 to 40 km (300 ft to 24 miles) wide. Long-period comets, those that take more than 200 years to orbit our Sun, such as Comet Hale-Bopp or Comet Hyakutake, may come from the Oort cloud.Īs ice bodies from the Kuiper belt or Oort cloud near the Sun, the ices begin to sublimate from a solid into a gas, and take the familiar shape of a comet. Objects in the Oort cloud are too small and far to be seen. The Oort cloud is a sphere that envelops our solar system and may extend 30 trillion kilometers (about 20 trillion miles) away from its center. Most short-period comets, those with orbits less than 200 years, such as Comet Halley, originate in the Kuiper belt.īeyond the Kuiper belt is the Oort cloud, which also contains icy remnants of our solar system's formation. Occasionally a Kuiper belt object may have a close encounter with Neptune or another body that flings the object out of the solar system or pushes it into a closer orbit where we may observe it periodically as a comet. Cometsīeyond the orbit of Neptune, there is a collection of small, icy planetary bodies that were left over from the formation of our early solar system. While large asteroid impacts with Earth are rare, small asteroids (falling as meteorites) impact the Earth every day! Scientists have collected more than 50,000 meteoritic samples of asteroids on Earth. M-type (metallic) asteroids are predominantly metallic iron and nickel.Īlthough it is difficult to return asteroid samples with spacecraft, nature routinely sends samples to Earth. These asteroids are composed of rocky materials and small amounts of metallic iron. Silicon-rich (S-type) asteroids dominate the inner part of the asteroid belt, closest to the Sun. These asteroids are usually composed of organic compounds and hydrated minerals. Most of the known asteroids (over 75%) are C-type (carbon-rich) asteroids, located in the outer region of the main asteroid belt. However, the largest asteroid, Ceres, has sufficient gravity to become nearly spherical, so it is also classified as a dwarf planet! Vesta, another large asteroid, has evidence of ancient lava flows on its surface.Īsteroids are classified by their composition. Most asteroids are irregularly shaped and all have craters from impacts with other asteroids. They range in width from 620 miles (1000 kilometers) down to dozens of meters. Though thousands of asteroids reside in the main belt, this region is not densely populated - all of the asteroids together only make about 5% the mass of the Moon.Īsteroids come in many sizes and shapes. Many of them reside in the asteroid belt that lies between the inner and outer planets. AsteroidsĪsteroids are leftovers from planetary formation. Photo mosaic of images taken by Galileo spacecraft of asteroid Ida. Anything that has 6 unique flavors, you can combine in any order, or a game with 6 possible moves you could do in any order is another factorial. The order you spend your time is a factorial you use everday without thinking. This is not practically useful but shows the power of possibilities. If making a chore list of 12 items you would find, that $12!$ is $12\times11\times10\times9\times8\times7\times6\times5\times4\times3\times2\times1=479,001,600$ possibilties. So in this example $4!$ is $4\times3\times2\times1=24$ possibilties. By multiplying you find the total number of combinations you could dwell on before you begin a game. You multiply each remaining number underneath 4 until you get to 1 then stop. In this case you start with 4 slots to fill on your team. The number of possibilities depends on what total number of teammates you have. You can arrange Sonic and any other person on your team to come up with the best team to win the race. You can put Sonic first, or second or third or fourth. I am using Mario and Sonic at the Olympic Games as an example. Or anytime you have the capability to do a number of acrivities in any order, like a chore list. Think of any video game, or a track meet relay, where you pick players to go first, second, third or fourth in a race. Here is a plot together with the gamma function, or to be more precise, $\Gamma(x 1)$: Plot "factorial" using 1:2 with linespoints Drop that part or try different plotting options, see "help plot" within gnuplot. A Bézier curve is an interpolation function. You ordered that interpolation via "smooth bezier".During a mathematical education program you will usually encounter it in calculus, for example Taylor's theoremį(x) = \sum_.I've very limited knowledge in mathematics - say school level - I'd prefer a simple answer which can be related to easily The value of the factorial between two integers. For example, to write the factorial of 6, you would write 6. I want to know how this software interpolates A factorial is written as the number followed by an exclamation point. I plotted the following range of numbers with its factorial using.We would never tend to arrange like 2.5 (two-and-a-half) items. In this lesson, youll create some very simple functions (they are each only two lines of Freemat code) to add to those already available in Freemat. I'm reading about the gamma function to be used for findingįactorials of non-integers (decimals). f factorial(n) Here n is a non-negative integer value and this function will result in a product of all positive integers whose value will either be equal.What are the other applications than arranging number of items.Solution: Using the factorial rule, we can write. I understand that a factorial of n items gives you the number of ways you can arrange the given items.įor example: If there are two coins - you can arrange them in two different ways - like wise if you have 3 coins - there are 6 ways you can arrange them. When doing factorials, it is advisable to apply the factorial rule whenever possible to simplify expressions, as shown in the examples below. I searched the math.stackexchange and could not find an answer. Lets see how it works with some more examples. So if you were to have 3, for example, youd compute 3 x 2 x 1 (which 6). It represents the multiplication of all numbers between 1 and n. In mathematics, the factorial of a non-negative integer n distinct objects into a sequence.I'm trying to understand the practical application of factorial - in simple applications. A factorial is a mathematical operation that you write like this: n. Selected factorials values in scientific notation are rounded For data representation by independent components, see factorial code. For statistical experiments over all combinations of values, see factorial experiment. This article is about products of consecutive integers. For more information check out the documentation.Īs of January 1st 2017, ReShade is open sourced under the terms and conditions of the BSD 3-clause license! You can help development with your own contributions via the official GitHub repository. ReShade 5.0 introduced a powerful add-on API that makes it possible to write add-ons for both ReShade and the games it is used with. Write your shaders just once, they'll work everywhere, regardless of your target being Direct3D or OpenGL: ReShade takes care of compiling them to the right shader model and language (HLSL, GLSL or SPIR-V). The syntax is based on HLSL, adding useful features designed for developing post-processing effects: Define and use textures right from the shader code, render to them, change renderstates, retrieve color and depth data, request custom values like timers or key states. ReShade features its very own shading language and compiler, called ReShade FX. i uninstalled the game with intent to reinstall but the 'setup' version i have is giving me the same problem. it said something about not being able to complete version check or some such. LEARN MORE 29. I logged out of the game for a few hours and when i returned, the game would not launch. NET Framework 4.6.2 or higher installed is required. FINAL FANTASY XIV: ENDWALKER DIGITAL COLLECTORS EDITION Dive into the next chapter of the critically acclaimed FINAL FANTASY® XIV Online with the latest expansion packENDWALKER The Digital Collectors Edition also contains bonus in-game items to aid you in your adventures. ReShade supports all of Direct3D 9, Direct3D 10, Direct3D 11, Direct3D 12, OpenGL and Vulkan.Ī computer with Windows 7 SP1, 8.1, 10 or 11 and. Malcolm McDowell in A Clockwork Orange is another notable example of the continued relevance of the codpiece in recent popular culture, while Darth Vader and the Stormtroopers in Star Wars surely took style notes from the well-endowed armoury of Henry VIII. “This time around, it serves to enhance the virile appeal of other kinds of mightily eye-catching men, all equally glitzy in their own fields,” Glover muses. Take “crooners and thrusters” like David Bowie, Michael Jackson and Alice Cooper, who have all taken advantage of a well-stuffed crotch. The codpiece might have sunk from favour almost as quickly as it was embraced by polite society, but its legacy undeniably lives on. “As with all other fashionable codpieces of the moment, these metal iterations were exaggerated in size and pugnacious in attitude.” Codpiece of King Henry VIII, 1540. Glover explains that armoured codpieces would have been a familiar sight on the battlefields this particular specimen belonged to Henry VIII himself, and remains on view at the Tower of London. In another image, a detail of a suit of armour reveals a sizeable bulge. Peasants dance in revelry at a wedding, the codpieces on each male guest unmistakably in view. In a raucous painting by Pieter Bruegel the Elder, a scene far removed from the royal court or privy chamber is shown in full swing. “Above it all there hovers a pretty, nattily tied bow of yielding fabric, as if the king’s genitals were a gift to the fortunate.” “Solid, steady, sturdy, purposeful, he shows off his magnificent organ of generation in all its cloth-pampered semirotundity,” Glover writes, tongue firmly in cheek. The fallibility of human ambition and self-presentation is laid bare, like the particularly loud revving of a shiny new sports car.Ī study for a portrait of Henry VIII by Hans Holbein the Younger (the final work was tragically destroyed in a fire) shows him with legs astride and codpiece jutting out. Frequently eye-popping, with the codpiece as their focus, they bring a welcome sense of light relief and humour to the all-too familiar formal portraits of art history. When displayed together, they are revealed in a startling new light. Pinacoteca di Brera, MilanĪ rich array of paintings by the likes of Titian, Parmigianino and Hans Holbein the Younger are showcased. Giovanni Battista Moroni, Portrait of Antonio Navagero, 1565. The codpiece could come in handy, though, doubling for some as a pocket or purse in one case, a nobleman suspended his spectacles from it when they weren’t in use. Glover compares it to the powdered wig and Cuban heel that came later, all equally absurd in their performance of male braggadocio. No longer just a piece of clothing, the codpiece went high fashion.Įasily individualized and decorated with the finest of fabrics, “complete with ribbons and bibbons and other bits of nonsense”, the codpiece was a tool for powerful men to make a statement of their virility and sexual prowess. From its origins as a gesture of modesty and means of concealing the genitals, it quickly grew into a garment that drew attention and aggrandized them to a ridiculous degree. “Sadly for its admirers, the codpiece was fashionable for a mere half century or so, starting around 1540,” Glover states. Museo Nacional del Prado, MadridĬatchily named Thrust: A Spasmodic Pictorial History of the Codpiece in Art, this little gem of a book explores the unique place of the codpiece in visual culture. Titian, Emperor Charles V with a Dog, 1533. “Little by little, the codpiece expanded in size, snarl and just-look-at-me ambition,” Michael Glover explains in his potted and informal history of the garment. A triangular flap of linen at first, the codpiece was intended to cover the drafty and revealing gap between the two separate pieces of men’s stockings. Not so when it comes to the codpiece, a curious phenomenon of sixteenth-century fashion that left little to the imagination. While the humble bulge might draw attention in the vice grip of a particularly tight pair of jeans, its sexual allure lies in the power of suggestion rather than the big reveal. But for a society seemingly so obsessed with the penis, sartorial enhancements to the appendage itself are surprisingly rare. Parmigianino (Girolamo Francesco Maria Mazzola), Pietro Maria Rossi, Count of San Secondo, 1535–1538įrom skyscrapers to space rockets to historic monuments, phallic symbols dominate our visual landscape. However, these independent playlists often carry lower subscriber/listener rates than editorial ones. They’ll build up some playlists and once they have a good following, artists come to them! These playlist curators are easier to access for artists and labels and are perhaps more likely to have the perfect niche playlist. Many curators who are just starting out use streaming platforms as a way to build a portfolio and practice their curator skills. In the digital age, these in-house curators are inundated with artists and labels all trying to secure a spot in a popular playlist. After all, some say playlists are the new radio! The curator must update these playlists on a regular basis and keep selected songs relevant to the playlist’s theme in order to keep fans engaged.Ĭurators in this sector can make or break a new release as most editorial playlists have thousands of subscribers. It’s their job to create popular playlists that music fans will listen to on a frequent basis encouraging subscriptions to the service. Streaming curators work in-house for streaming services like Spotify and Apple Music. They’ll then use this music for different purposes, depending on the type of music curator… Streaming Curators Music is consumed everywhere in day to day life - You hear it on the TV, in shops, in gyms and everywhere in between! But, did you know, it’s actually someone’s job to choose the songs you hear when you buy your morning coffee or listen to a playlist on your way to work? That’s right, it isn’t any old random mix of music! It’s been cleverly designed by music curators who get paid to listen to music… What Is A Music Curator?Ī music curator spends their day listening to music – Sounds like a perfect job to me, getting paid to listen to music! However, it does get a little more complicated than that… A curator will listen to and categorise music from labels and independent artists often receiving hundreds of song applications a day! They will categorise them by genre, feel, instrumentation, male or female vocals and anything else you can think of! The more specific the categorisation, the easier it makes the curators job. |